Henna (Lawsonia inermis) has a long history of traditional use in various cultures, primarily for its cosmetic and dyeing properties. In the context of headache, especially tension-type headaches, some traditional medicinal systems—such as Unani and Ayurveda—mention the application of henna paste or oil to the scalp or forehead as a remedy to relieve pain. The rationale is often linked to the supposed cooling and soothing effects of henna when applied topically, which are believed to ease tension and provide relief from headache symptoms.

However, there is a notable lack of modern scientific research or clinical trials validating the efficacy of henna in the treatment or relief of headaches. No robust biochemical or pharmacological mechanisms have been established to support its use for this purpose. Most of the available evidence is anecdotal or found in traditional texts rather than peer-reviewed scientific literature.

Therefore, while the use of henna for headaches is justified by tradition in certain cultures, it cannot be considered a scientifically supported therapy. The evidence for its effectiveness is minimal, and it should not replace evidence-based medical approaches to headache management.