Evidence supporting the use of: Andrographolide
For the body system: Heart
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Andrographolide, a diterpene lactone extracted from Andrographis paniculata, has been investigated for its potential cardiovascular benefits. Preclinical studies in animal models and in vitro experiments have demonstrated that andrographolide possesses anti-inflammatory, antioxidant, and anti-atherosclerotic properties, which may contribute to cardiovascular protection. Several studies have shown that andrographolide can reduce oxidative stress and inhibit inflammatory cytokines, thereby protecting vascular endothelial cells and reducing the progression of atherosclerosis. There is also evidence suggesting that andrographolide can improve lipid profiles and lower blood pressure in animal models, which are relevant factors for heart health.
However, clinical evidence in humans remains limited. A few small-scale clinical trials have explored the effects of Andrographis paniculata on cardiovascular risk factors, but the findings are preliminary and not sufficiently robust to make definitive recommendations for its use in supporting heart health. Most of the available evidence comes from laboratory and animal research rather than large, well-controlled human studies. Nevertheless, the mechanistic data and preclinical results provide a scientific rationale for investigating andrographolide further as a potential adjunct in cardiovascular health.
In summary, the use of andrographolide to support the heart is justified by preclinical scientific evidence, but more high-quality human studies are needed to confirm its efficacy and safety in this context.
Other ingredients that support Heart
1,3,7-Trimethylpurine-2,6-dioneAcacetin
Acai berry
Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
Adrenergic amines
Adzuki bean
Agarwood
Ajoene
Alcohol
Alfalfa
Algae
algal oil
Algal protein
Allicin
Alliin
Allium tuberosum
Almond fruit
Alpha phytosterol
Alpha-carotene
alpha-linolenic acid (ALA)
alpha-lipoic acid
amaranth
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
anchovies
andrographolide
animal protein
anthocyanidins
anthocyanins
anthocyanosides
Antrodia camphorata
apigenin
apocynin
apple
apple cider vinegar
apricot
argan nut oil
Arginine aspartate
arginine creatine
Arginine malate
Arginine nitrate
Arginine orotate
Arginine silicate
arjun tree
arjuna
arjunic acid
Arjunolic acid
Aronia melanocarpa
ashitaba
Ashoka
ashwagandha
astaxanthin
Asteraceae
astragalin
astragaloside
astragalus
avocado
bael
baicalein
baicalin
balsam
bamboo
banana
barley
basil
bayleaf
bean
bee pollen
bee products
bee propolis
Beef liver
beet
belleric myrobalan
benfotiamine
berberine
bergamot
berry
beta and delta tocopherols
beta-hydroxybutyrate
beta-sitosterol
betanin
bignay
bilberry
bioflavonoids
bishop\'s weed
black cumin
black currant
black garlic
black ginger
black seed
black tea
blackberry
blubber oil
blueberry
Boerhavia diffusa
bonito peptide
borage
borneol
bottle gourd
bovine heart
Brassica
Brazil nut
breadnut
broccoli
Brussel sprouts
brutieridin
Buckwheat
buffalo
bugleweed
butylphthalide
C-phycocyanin
cactus
caffeic Acid
caffeine
calamari oil
Calanus finmarchicus
calcium
calycosin
camelina oil
Camellia sinensis
campesterol
capers
capsaicin
capsaicinoids
capsicum
cardamom
cardiolipin
Carnosine
carnosol
Carthamus
Casearia sylvestris
cassia bark
catalpol
catechins
catecholamine
caterpillar mushroom
cayenne pepper
celery
Cereus
cha de bugre
chaga mushroom
cherry
chia seed
chia seed
Chinese salvia root
Chinese thoroughwax
chlorogenic acid
chocolate
chokeberry
chrysanthemum
Cinnamomum
cinnamon
Citrus
citrus bioflavonoids
citrus sinensis (proprietary)
Clerodendrum trichotomum
cocarboxylase
cocoa
Coconut Water
cod liver oil
Codonopsis
coenzyme Q10 (CoQ10)
cola nut
Coleus forskohlii
collard
commiphora
copper
cordyceps
coriander
cortisol
Corydalis
creatine
crocetin
cruciferous
Curcuma
curcumin
Curcuminoid
currant
curry leaf
cuspidatum root
cutch
cyanidin
Cyclanthera pedata
d-alpha tocopherol
D-Ribose
danshen
date
deer velvet
dextrose
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
Digitalis
dihydrolipoic acid
dismutase
docosahexaenoic Acid
dong quai root
DPA (docosapentaenoic acid)
dulse
durian
Echium
egg
eicosapentaenoic acid
electrolytes blend (proprietary)
eleuthero
emblicanin
EPA (eicosapentaenoic acid)
ephedrine
epicatechin
epigallocatechin gallate (EGCG)
ergothioneine
eriocitrin
Erythrina
essential oil blend
Eucommia ulmoides
Evodia
Fagopyrum
fat liver oil
fatty acids
ferulic acid
fiber
fibroblast growth factor
Ficus religiosa
figwort
fisetin
fish
fish oil
fish protein
flavanols
flavanones
flavans
flavin mononucleotide
flavoglycosides
flavones
flavonoids
flavonols
flavonones
flaxseed
fo-ti
folate
folic acid
formononetin
forskohlii root
forskolin
foxglove
Foxtail millet
fruit
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
fu ling
fucosterol
fungus
furostanols
ganoderma
garbanzo bean
gardenia
Gardenia jasminoides
garlic
garlic bulb
ginger
Ginkgoside
ginseng
Ginsenosides
glucomannan
glucose
Glycoside
GMS-ribose
gokhru
gooseberry
grape
Greek mountain tea
green tea
greens blend (proprietary)
Guava
guggul
Guggulsterones
Gypenoside
hawthorn
hazelnut
heal-all
hemp oil
herbal blend (proprietary)
hesperetin
hesperidin
hibiscus
Higenamine
holly
honey
Honokiol
horse gram
hydroxyphenylethanols
hydroxytyrosol
Hyperoside
Ilex
Immortelle
inositol nicotinate
inula racemosa
iron
isoliquiritigenin
isoquinoline alkaloids
Jaboticaba
Jatamansi
jiaogulan
jujube
Kaempferol
kale
knotgrass
knotweed
kola nut
krill oil
kuding tea
kudzu
Kumquat
L-arginine
l-carnitine
L-citrulline
L-taurine
Lactotripeptides
Large-leaved linden
Legume protein
lemon
Lentil
lignans
Ligusticum
Ligustrazin
lily
linden
lingzhi
linoleic acid (LA)
linseed oil
lipids
longan
Loranthus
lotus
lotus seed
lumbrokinase
luteolin
lycopene
macadamia
magnesium
magnesium
mangiferin
mango
mangosteen
maqui berry
Marine fat
Marine lipid
Marine protein
Marjoram
Marking Nut Tree
Maslinic acid
Matcha
Mate
Mealy Kudzu
Methoxylated flavones
Methylxanthine
Milkweed
Mineral ascorbate
mixed carotenoids
Molasses
Monacolin
Monounsaturated fat
Morinda
Moringa
Motherwort
Mountain mahogany
Mulberry
Mung bean
Mushroom
mustard seed
Myricetin
Myricitrin
Myrobalan
N-acetyl-cysteine (NAC)
N-Coumaroyldopamine
NADH
Nannochloropsis
Nardostachys
Naringenin
Naringin
Nattokinase
Nattozimes
Niacin (vitamin B3)
nicotinamide riboside
Nigella seed
Nobiletin
noni
Nymphaea caerulea
Nymphaea nouchali
oat
okra
oleanolic acid
oleic acid
Oleoperin
Oleuropein
Oligomeric proanthocyanidins
olive
omega-3 fatty acids
omega-6 fatty acids
omega-7 fatty acids
omega-9 fatty acids
onion
Onosma bracteatum
oolong tea
Ophiopogon
ophiopogon root
oriental arborvitae
oyster mushroom
pagoda tree
palmitoleic acid
pantethine
parsley
Passionfruit
peach
peanut
Pentacyclic triterpenoids
Peptides
Persimmon
phenolic compounds
Phenylpropanoids
phlorotannins
Phosphocreatine
phospholipids
Phthalides
Phyllanthus
phytosterols
pine bark
Pistachio
Plankton
plant sterols
plum fruit
policosanol
pollen
Polydatin
Polygonatum
Polygonum
polymethoxylated flavones
polyphenols
polyunsaturated fat
pomegranate
pomelo
potassium
prepared aconite tuber
prickly ash
proanthocyanidins
procyanidin
Propionyl-L-Carnitine
protein
Prunus
psyllium
pu-er tea
Puerain
Puerarin
pumpkin
punarnava
punicalagins
punicosides
Purple milkweed
purple tea
purslane
Pycnogenol
pyrroloquinoline quinone
pyruvate
quercetin
quinoa
Quinoa Protein
rapeseed oil
Rauvolfia
red clover
red yeast
red yeast rice
Rehmannia
rehmannia glutinosa
reishi mushroom
resveratrol
rhizome
Rhododendron
Rhus coraria
Rhus coriaria
Rhus glabra
ribose
Rooibos
Rosa roxburghii
Rosabin
rosavins
rose
rose oil
rosemary
Rosy conk
Rubiaceae
rue
Rutaecarpine
rutin
Rutosides
rye
S-allylcysteine
Sacha Inchi
safflower oil
saffron
Salba Oil
Salidroside
Salmon Oil
salt
Salvia
Salvianolic acid
Schisandrins
Schizochytrium
Schizochytrium Oil
Scoparia dulcis
Scotch Broom
secoisolariciresinol diglucoside
selenium
Semecarpus anacardium
sesame
Sesamin
Sete sangrias
Shankhpushpi
Shilajit
Sichuan Lovage
Sida cordifolia
sitostanol
Sitosterol
Snakeroot
soursop
Soy
soy isoflavones
Soy Protein
soybean
Spantholobus
Spatholobus
specialized pro-resolving mediators (SPMs)
Sphaeranthus indicus
Spikenard
spinach
spirulina
Stearidonic acid
sterols
Stigmastanol
Stilbenoid
Stone Root
strawberry
Sulforaphane
sulforaphane glucosinolate
Sumac
sunflower
Sunflower oil
Szechuan lovage
Tamarind
Tanshinone
Taurine
Taxifolin
Tea
Tejocote
Terminalia
Terpenoids
Theaflavin
Theobromine
Thiamin (vitamin B1)
Thymoquinone
Tiger Nut
tocotrienols
trace minerals
Trans-pterostilbene
tribulus
Tribulus Terrestris
Tridax
Trimethylglycine (TMG)
Triphala
Triterpenes
Tropical jewel hisbiscus
Troxerutin
Tulbaghia
turmeric
Tynanthus panurensis
Tyrosol
ubiquinol
Urolithin A
Valyl-Prolyl-Proline
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vegetable oil
Vegetable Protein
Vervain
Vine tea
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
vitamin E
vitamin K
Vitexin
Walnut
Watercress
Watermelon
Wax Gourd
wheat germ
White Tea
Wood betony
Xanthine
Xanthohumol
Xantinol Nicotinate
Yarrow
Yerba mate
Ylang ylang
Yumberry
Yuzu
Zinc
β-nicotinamide mononucleotide (NMN)
Other body systems supported by andrographolide
Digestive SystemGastrointestinal Tract
Heart
Hepatic System
Immune System
Intestinal System
Liver
Lungs
Respiratory System
Spleen
Stomach