Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-arginine is an amino acid that serves as a precursor to nitric oxide, a molecule that helps relax and dilate blood vessels, thereby supporting vascular health and blood flow. Its role in cardiovascular support has been investigated in various clinical and experimental settings. Some studies suggest that L-arginine supplementation can improve endothelial function, lower blood pressure in certain populations, and increase exercise capacity in individuals with stable angina or peripheral arterial disease. However, the evidence is mixed and often limited by small sample sizes, short study durations, and variability in patient populations and dosages used.

Systematic reviews and meta-analyses generally conclude that while L-arginine may have modest benefits for blood pressure and endothelial function, these effects are not consistently strong or clinically significant, especially in otherwise healthy individuals or those with advanced cardiovascular disease. Notably, some studies have raised concerns about potential adverse effects, such as increased mortality post-myocardial infarction in specific patient groups. Major cardiology guidelines do not currently recommend routine L-arginine supplementation for cardiovascular disease prevention or treatment. Therefore, while there is a scientific rationale and some supporting evidence, the overall strength and clinical importance of the evidence remain limited.

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