Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Leucoanthocyanins, more commonly referred to as proanthocyanidins or condensed tannins, are polyphenolic compounds found in various plants, including grapes, apples, cocoa, and pine bark. Their use to support the heart and cardiovascular system is primarily backed by scientific evidence, though the strength of evidence remains moderate rather than conclusive. Multiple experimental and clinical studies have shown that leucoanthocyanins possess strong antioxidant properties, which help reduce oxidative stress—a key factor in the development of atherosclerosis and other cardiovascular diseases.

Some clinical trials, particularly with extracts rich in proanthocyanidins such as those from grape seed or pine bark (Pycnogenol), have reported improvements in endothelial function, reductions in blood pressure, and inhibition of LDL cholesterol oxidation. These mechanisms are believed to contribute to cardiovascular protection. For example, a meta-analysis published in the Journal of the American College of Nutrition (2011) found that grape seed extract supplementation could modestly reduce systolic blood pressure. However, further large-scale, long-term studies are needed to confirm these effects and determine their clinical significance.

While leucoanthocyanins are not a mainstream therapy for heart disease, their inclusion in dietary supplements aimed at cardiovascular health is supported by a growing, though not definitive, body of scientific literature. Their use is not merely traditional but has a scientific rationale, although the strength of this rationale warrants a moderate evidence rating.

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Products containing Leucoanthocyanins

We currently have no products on Vitabase that contain this ingredient.