Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Trimethylglycine (TMG), also known as betaine, has been studied for its effects on cardiovascular health, primarily due to its role as a methyl donor in the body. TMG participates in the methylation of homocysteine to methionine, a process that helps lower plasma homocysteine levels. Elevated homocysteine is considered a risk factor for cardiovascular diseases, including heart attack and stroke. Several clinical trials have demonstrated that TMG supplementation can effectively reduce homocysteine concentrations in the blood. However, while lowering homocysteine is theoretically beneficial for heart health, large-scale clinical trials have not conclusively demonstrated that TMG supplementation leads to a reduction in cardiovascular events or mortality. As such, although there is a clear biochemical rationale and evidence supporting TMG’s ability to lower homocysteine (an established risk factor), direct evidence for prevention of heart disease outcomes remains limited. TMG is not commonly used in traditional medicine for heart health; its use is based on modern biochemical and clinical research. Overall, the scientific evidence supporting TMG for heart health is moderate, with benefits clearly established for homocysteine reduction but not definitively for clinical cardiovascular outcomes.

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