Relationship: Heart and vitamin D3

Evidence supporting the use of: Vitamin D3
For the body system: Heart

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D3 (cholecalciferol) has a scientifically supported, though moderate, role in supporting the cardiovascular (heart) system. Multiple observational studies have shown that low levels of vitamin D are associated with increased risks of cardiovascular diseases, such as hypertension, heart failure, and coronary artery disease. Mechanistically, vitamin D receptors are present in heart tissue and blood vessels, where vitamin D may influence vascular tone, inflammation, and glucose metabolism. Some interventional studies and meta-analyses have suggested that vitamin D supplementation can modestly reduce blood pressure, particularly in people who are deficient, and may improve some markers of cardiovascular health.

However, large randomized controlled trials (RCTs), including the VITAL study (2019), have generally found that vitamin D supplementation does not significantly reduce major cardiovascular events in the general population. The benefits appear to be more pronounced in specific subgroups, such as those with baseline deficiency or certain comorbid conditions. Therefore, while there is a plausible biological rationale and some evidence for using vitamin D3 to support heart health, the effect size is moderate and may not apply broadly. The current consensus is that vitamin D3 is not a primary therapy for heart disease but may be helpful in individuals with deficiency. Clinical guidelines recommend correcting vitamin D deficiency for general health, which may provide some cardiovascular benefits.

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Other body systems supported by vitamin D3

Blood
Brain
Circulatory System
Glandular System
Heart
Immune System
Intestinal System
Kidneys
Lungs
Mitochondria
Muscles
Parathyroid Glands
Respiratory System
Skeletal System (Bones)
Skin
Small Intestines
Teeth

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Health Concerns

Brands

Evidence supporting the use of: Vitamin D3
For the body system: Heart

Table of Contents

Synopsis

Other ingredients that support Heart

Other body systems supported by vitamin D3

Products containing vitamin D3

Health Concerns

Brands

Evidence supporting the use of: Vitamin D3For the body system: Heart

Table of Contents

Synopsis

Other ingredients that support Heart

Other body systems supported by vitamin D3

Products containing vitamin D3

Evidence supporting the use of: Vitamin D3
For the body system: Heart