Evidence supporting the use of: Ubiquinol
For the health condition: Heart Fibrillation or Palpitations

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ubiquinol, the reduced and active form of coenzyme Q10 (CoQ10), is sometimes used as an adjunct supplement in cardiovascular health, including for heart arrhythmias such as atrial fibrillation or palpitations. The scientific evidence supporting its use in these conditions is limited but not absent. Several small clinical studies and observational data suggest that CoQ10 (including ubiquinol) may improve certain parameters of cardiac function, particularly in patients with heart failure or those undergoing cardiac surgery, where oxidative stress and mitochondrial dysfunction are implicated. Some mechanisms proposed include improvement in cellular energy production, stabilization of cardiac cell membranes, and reduction of oxidative stress, all of which could theoretically reduce arrhythmogenic potential.

However, there is a lack of large, high-quality randomized controlled trials specifically targeting atrial fibrillation or palpitations as primary outcomes. Most studies focus on broader cardiac endpoints, and the few that mention arrhythmias often include them as secondary measures or observational findings. The evidence for ubiquinol reducing palpitations or the incidence of atrial fibrillation is therefore indirect and not robust. Guidelines from major cardiology societies do not currently recommend ubiquinol or CoQ10 as standard therapy for these arrhythmias, and any benefit is considered adjunctive and not primary. In summary, while there is some scientific rationale and preliminary data for ubiquinol's use in heart rhythm disturbances, the evidence is weak (rated 2/5), and more research is needed to establish clear efficacy.

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