Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Coenzyme Q10 (CoQ10) for Heart Weakness (Heart Failure) – Scientific Evidence

Coenzyme Q10 (CoQ10) is a naturally occurring antioxidant present in the mitochondria of cells and plays a critical role in cellular energy production. Its use in supporting heart health, particularly in cases of heart weakness or heart failure, is backed by a moderate but growing body of scientific evidence.

Several clinical trials and meta-analyses have found that CoQ10 supplementation may improve symptoms and quality of life in patients with chronic heart failure. The Q-SYMBIO trial (2014), a well-known randomized controlled study, demonstrated that patients with moderate to severe heart failure who received 300 mg of CoQ10 daily had a significant reduction in major adverse cardiovascular events and mortality compared to placebo. Other studies have shown improvements in ejection fraction (a measure of heart pumping ability), exercise capacity, and reductions in hospitalizations.

CoQ10 levels are often lower in people with heart failure, and statin medications (commonly prescribed for heart disease) can further reduce CoQ10 levels. Supplementing CoQ10 may help restore these deficiencies and enhance mitochondrial energy production in heart muscle cells.

While major cardiology guidelines do not yet universally recommend CoQ10 as a standard therapy, its safety profile is favorable and evidence continues to accumulate. Overall, the scientific support for CoQ10 in heart weakness is moderate, meriting a score of 3 out of 5.

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Products containing coenzyme Q10 (CoQ10)

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Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
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Pure Encapsulations PureGenomics® UltraMultivitamin
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Douglas Laboratories Ultra Preventive One Daily
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