Evidence supporting the use of: Glycoside
For the health condition: Heart (weakness)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Glycosides, particularly cardiac glycosides such as digoxin and digitoxin, have a well-established role in the treatment of heart failure and certain cardiac arrhythmias. These compounds are derived from plants like Digitalis purpurea (foxglove) and have been used medicinally since the 18th century. Their primary mechanism of action is the inhibition of the sodium-potassium ATPase pump in cardiac myocytes, which leads to an increase in intracellular calcium levels. This results in increased myocardial contractility (positive inotropic effect), making them especially useful in cases of heart failure characterized by reduced ejection fraction or "weakness" of the heart muscle. Extensive scientific research and clinical trials have validated the efficacy of cardiac glycosides in improving symptoms, exercise tolerance, and quality of life in patients with heart failure. Additionally, digoxin is used in the management of certain supraventricular arrhythmias, such as atrial fibrillation, due to its effects on atrioventricular conduction. However, their use requires careful dosing and monitoring due to the narrow therapeutic window and risk of toxicity. In summary, the use of glycosides for supporting or treating heart weakness is strongly supported by both historical use and modern scientific evidence, with clear mechanisms of action and proven clinical benefits in appropriate patient populations.

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