Honduran Sarsaparilla (Smilax regelii and related species) has a long history of use in traditional medicine in Central America and the Caribbean. Traditionally, sarsaparilla roots have been used as a general tonic, blood purifier, and remedy for various ailments, including "weakness of the heart" or general debility, though these terms were often broad and non-specific in historical records. Folk healers sometimes recommended sarsaparilla as part of mixtures aimed at improving vitality or circulation, which could be interpreted as supportive of heart health in a general sense.

However, there is little scientific evidence to support the use of Honduran sarsaparilla specifically for treating heart weakness or any cardiovascular condition. Modern pharmacological studies on sarsaparilla have focused mainly on its potential anti-inflammatory, immune-modulating, and antimicrobial activities. There is no robust clinical research demonstrating direct benefits for heart function or for the treatment of cardiac weakness. The use for heart-related issues remains based on traditional practices rather than validated efficacy.

In summary, Honduran sarsaparilla’s use for heart weakness is rooted in traditional medicine rather than scientific validation, and the supporting evidence is very limited.