Evidence supporting the use of: Orotic acid
For the health condition: Heart (weakness)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Orotic acid has a documented history of use in cardiovascular research, particularly in Eastern Europe and Russia, as a supplement thought to support heart health and address "heart weakness" (a non-specific term that may refer to heart failure or reduced cardiac function). Orotic acid is a naturally occurring compound involved in pyrimidine biosynthesis. Its salt form, magnesium orotate, has been studied more extensively than orotic acid itself for cardiac support. Several animal studies from the mid-20th century suggested that orotic acid supplementation could improve cardiac function after myocardial injury, possibly by facilitating nucleic acid synthesis and cellular repair. Some small clinical trials in the 1970s and 1980s reported that magnesium orotate supplementation improved exercise tolerance, cardiac output, and survival in patients with heart failure compared to magnesium alone or placebo. However, these studies were generally small, not always well-controlled, and have not been widely replicated or validated in larger, high-quality trials. Current mainstream cardiology guidelines do not recommend orotic acid or magnesium orotate for heart failure or other cardiac conditions due to insufficient evidence. The use of orotic acid for "heart weakness" is thus based on limited scientific evidence, with some early studies suggesting benefit but lacking strong, contemporary validation. More robust, modern clinical trials would be needed to establish efficacy and safety.

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Other health conditions supported by orotic acid

Heart (weakness)

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