Evidence supporting the use of: Stem Cells
For the health condition: Heart (weakness)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Stem cells have been investigated as a potential treatment for heart weakness, particularly in conditions such as heart failure resulting from myocardial infarction (heart attack). The scientific rationale is based on the ability of certain types of stem cells—such as mesenchymal stem cells (MSCs) or induced pluripotent stem cells (iPSCs)—to differentiate into cardiac-like cells or to secrete factors that promote repair and regeneration of heart tissue. Preclinical studies in animal models have shown that stem cell therapies can improve cardiac function, reduce scar size, and stimulate angiogenesis (formation of new blood vessels). Early-phase clinical trials in humans have demonstrated modest improvements in heart function, exercise capacity, and quality of life, although results have been variable and sometimes inconsistent. The mechanisms are thought to involve paracrine effects (release of growth factors and cytokines), rather than direct replacement of lost cardiomyocytes. Importantly, stem cell therapy for heart disease is still experimental; it has not become standard clinical practice and long-term safety and efficacy remain under investigation. Major cardiology societies recognize the potential but stress the need for more robust, large-scale randomized controlled trials before stem cells can be widely recommended for treating heart weakness. Thus, there is scientific investigation and early evidence, but it is not definitive or routine clinical care yet.

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