Evidence supporting the use of: Vitamin B1 (thiamine diphosphate)
For the health condition: Heart (weakness)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B1, also known as thiamine (in its active form, thiamine diphosphate), is scientifically recognized for its role in cardiovascular health, particularly in individuals with thiamine deficiency. Thiamine is a coenzyme essential for carbohydrate metabolism and energy production, processes that are vital for normal cardiac function. Severe deficiency of thiamine can lead to a condition known as wet beriberi, which is characterized by heart failure, edema, and other cardiovascular symptoms. Supplementation with thiamine in these cases can reverse cardiac symptoms and improve heart function. Furthermore, some studies have explored thiamine supplementation in patients with heart failure, especially those receiving long-term diuretic therapy (which increases the risk of thiamine deficiency), finding modest improvements in cardiac function such as left ventricular ejection fraction. However, robust evidence from large-scale, high-quality randomized controlled trials is lacking, and benefits in heart failure patients without thiamine deficiency are less clear. Thus, while there is scientific rationale and some clinical evidence for thiamine supplementation in cases of deficiency-related cardiac weakness, the overall evidence base for its use as a general treatment for heart weakness is moderate and mostly limited to specific populations at risk for deficiency.

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