Evidence supporting the use of: Vitamin E (alpha-tocopherol)
For the health condition: Heart (weakness)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (alpha-tocopherol) has been studied for its potential role in supporting heart health, particularly in relation to cardiovascular disease and heart failure (sometimes described as “heart weakness”). The scientific interest stems from vitamin E’s antioxidant properties, which theoretically could protect against oxidative stress implicated in the progression of atherosclerosis and heart muscle dysfunction. Observational studies in the late 20th century suggested that people with higher vitamin E intake had lower rates of heart disease. However, large randomized controlled trials, such as the HOPE and GISSI-Prevenzione trials, found that vitamin E supplementation did not significantly reduce cardiovascular events or mortality in patients at risk for or with established heart disease. Some studies even suggested a potential increase in risk at high doses. Guidelines from major health organizations do not recommend vitamin E supplementation for the prevention or treatment of heart disease. Therefore, while there is scientific interest and a plausible biological rationale, current evidence from high-quality clinical trials does not support the use of vitamin E to treat or improve “heart weakness,” and its efficacy is rated as low (2/5). It may still be justified for individuals with frank vitamin E deficiency, but not for general cardiovascular support.

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Products containing Vitamin E (alpha-tocopherol)

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