Evidence supporting the use of: Acetyl-l-glutathione
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Acetyl-L-glutathione is a stabilized form of glutathione, a tripeptide composed of glutamine, cysteine, and glycine, which is a key antioxidant in cellular defense systems. Glutathione plays a critical role in hepatic (liver) detoxification processes, particularly in neutralizing reactive oxygen species and facilitating the conjugation and elimination of various toxins. The rationale for using acetyl-L-glutathione as a supplement is that oral glutathione is rapidly broken down in the digestive tract, whereas the acetylated form is thought to be more bioavailable and capable of increasing systemic glutathione levels, including in the liver. Several animal studies and limited human studies suggest that increasing glutathione levels can support liver health, especially in conditions of oxidative stress or toxin exposure. However, direct evidence from controlled clinical trials specifically investigating acetyl-L-glutathione’s effects on liver function is limited. Most available research focuses on glutathione in general, not the acetylated form. While acetyl-L-glutathione may theoretically benefit hepatic detoxification, the evidence base is modest and mainly extrapolated from studies on glutathione itself. In summary, while there is scientific rationale and some preliminary evidence supporting acetyl-L-glutathione for hepatic system support via its role as an antioxidant and detoxification molecule, high-quality human data specific to this compound are lacking. The evidence, therefore, can be considered modest but plausible.

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Other body systems supported by Acetyl-l-glutathione

Brain
Hepatic System
Immune System
Mitochondria

Products containing Acetyl-l-glutathione

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