Evidence supporting the use of: Alpha ketoglutarate
For the body system: Hepatic System

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-ketoglutarate (AKG) is an intermediate in the Krebs (citric acid) cycle and plays a crucial role in cellular energy production. Its use in supporting the hepatic (liver) system is based on some scientific rationale, though robust clinical evidence in humans is limited. Experimental studies, primarily in animal models, suggest that AKG may help reduce liver injury and improve liver function under certain conditions. For example, AKG has been shown to reduce ammonia levels, which can benefit individuals with hepatic encephalopathy or compromised liver function. Animal studies have also indicated that AKG supplementation may reduce markers of oxidative stress and inflammation in the liver, potentially helping to protect hepatocytes from damage. Some researchers have studied its role in parenteral nutrition formulas for critically ill patients, including those with liver dysfunction, with mixed results. However, large-scale, well-controlled clinical trials in humans are lacking, and the evidence for routine use of AKG as a liver supplement in the general population is not robust. While the scientific rationale is plausible and there are some preclinical and limited clinical data, the overall evidence remains moderate at best, earning a score of 2 out of 5.

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