Evidence supporting the use of: Alpha-Ketoglutarate
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-Ketoglutarate (AKG) is a key intermediate in the Krebs cycle, central to cellular energy production and amino acid metabolism. Its use in supporting the hepatic (liver) system is based on its metabolic role and some scientific studies, though robust clinical evidence in humans is limited. Preclinical research and a few clinical studies suggest that AKG may help modulate ammonia levels, which is relevant in liver dysfunction—especially in conditions like hepatic encephalopathy. AKG acts as a precursor for glutamine and glutamate, supporting nitrogen balance and potentially aiding in the detoxification processes of the liver. Animal studies have demonstrated hepatoprotective effects, including reduced liver injury in models of toxin-induced hepatic damage, but these findings have not been strongly replicated in large-scale human trials. Additionally, some parenteral nutrition formulations contain AKG to support amino acid metabolism in patients with compromised liver function. Overall, while there is a clear scientific rationale for AKG’s use in hepatic support, especially in metabolic and detoxification pathways, the direct clinical evidence for significant liver protection or therapeutic benefit in humans remains limited. Therefore, the evidence rating is moderate but not strong.

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