Evidence supporting the use of: Bile acid
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Bile acids are endogenously produced compounds essential for the digestion and absorption of dietary fats and fat-soluble vitamins. In clinical practice, bile acids and their derivatives (such as ursodeoxycholic acid, or UDCA) are used therapeutically to support hepatic (liver) function. UDCA, in particular, is a well-studied bile acid with established efficacy in treating certain liver conditions, especially cholestatic liver diseases such as primary biliary cholangitis (PBC). Multiple randomized controlled trials and meta-analyses have demonstrated that UDCA can improve liver biochemistry, slow disease progression, and enhance transplant-free survival in PBC patients. Its mechanisms include reducing the cytotoxicity of endogenous bile acids, improving bile flow, and exerting anti-inflammatory and anti-apoptotic effects on hepatocytes.

Other bile acids, such as chenodeoxycholic acid, have also been used for specific hepatic disorders. While the use of bile acids is not universal for all liver diseases, their application in selected hepatic conditions is supported by strong scientific evidence and clinical guidelines. However, outside of these specific indications, routine supplementation with bile acids for general liver “support” in healthy individuals is not evidence-based and may carry risks. Thus, the scientific evidence for bile acid use is strong but primarily applies to distinct hepatic pathologies rather than general wellness or prevention.

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