Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Bupleurum falcatum has a long history of use in traditional Chinese and Japanese medicine, primarily as a liver-supportive herb. In Traditional Chinese Medicine (TCM), bupleurum (Chai Hu) is a key ingredient in formulas such as Xiao Chai Hu Tang ("Minor Bupleurum Decoction"), commonly prescribed for liver "qi stagnation," hepatitis, and related digestive complaints. Historical texts and centuries of empirical use attribute to bupleurum properties such as harmonizing the liver, alleviating stress-related symptoms, and supporting detoxification processes in the body.

Modern research on bupleurum and its active components (notably the saikosaponins) suggests potential hepatoprotective effects, including anti-inflammatory and antioxidant properties. Some in vitro and animal studies indicate that bupleurum extracts may help protect liver cells from damage caused by toxins and support regeneration. However, robust clinical trials in humans are lacking, and safety concerns (such as hepatotoxicity at high doses or with prolonged use) have also been raised in some case reports. As a result, while traditional use is well documented and there is some preliminary scientific interest, the evidence for its efficacy and safety in supporting the hepatic system is not yet conclusive by modern scientific standards.

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