Evidence supporting the use of: Chlorogenic acid
For the body system: Hepatic System
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Chlorogenic acid is a polyphenolic compound found in coffee, certain fruits, and vegetables. There is some emerging scientific evidence supporting its use for hepatic (liver) health, though this evidence is largely preclinical. Animal studies have indicated that chlorogenic acid may have hepatoprotective effects, such as reducing oxidative stress, lowering inflammation, and improving lipid metabolism in the liver. For example, rodent models of chemically induced liver injury have shown that chlorogenic acid administration can attenuate liver damage and markers of inflammation. Some mechanisms proposed include antioxidant activity, modulation of glucose and lipid metabolism, and anti-inflammatory effects.
However, human clinical data are limited. While some small studies suggest possible benefits in metabolic syndrome or non-alcoholic fatty liver disease (NAFLD), these findings are preliminary and not definitive. The majority of evidence is indirect, focusing on improved metabolic parameters rather than direct measures of liver function or disease outcomes. Chlorogenic acid is not widely recognized in traditional medicine specifically for liver support, so its use in this context is primarily based on modern research rather than longstanding practice.
In summary, while there is some scientific rationale and preclinical evidence for chlorogenic acid supporting the hepatic system, high-quality human studies are lacking. The current evidence base is modest, hence a rating of 2 out of 5.
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alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
animal protein
Antrodia camphorata
apigenin
Arginine carglumate
artichoke
baicalein
barberry
Basidiomycota
Beef liver
berberine
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betanin
bile acid
bile salt
bitter principals
black garlic
black seed
Boerhavia diffusa
boldo
borotutu
bovine
bovine liver
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broccoli
Bupleurum
bupleurum falcatum
capers
capillary artemisia
carqueja
catalpol
chanca piedra
Chinese thoroughwax
chlorogenic acid
cholic acid
Coenzyme A
corilagin
cruciferous
Curcuma
curcumin
Curcuminoid
cynarin
cynaropicrin
d-glucarate
dandelion
dehydrocholic acid
dihydrolipoic acid
dihydromyricetin
dithiolthiones
DL-Methionine
Eclipta
egg
emblicanin
epigallocatechin gallate (EGCG)
eriocitrin
ferulic acid
flavonolignan
fringetree
fungus
gallate
gamma-glutamylcysteine
ganoderma
garlic bulb
gentian root
Gentiana manshurica
Ginsenosides
glucose
Glycochenodeoxycholic acid
Glycocholic acid
Glycyrrhetinic acid
Glycyrrhizin
gooseberry
green tea
Guggulsterones
Gypenoside
herbal blend (proprietary)
hesperetin
isoliquiritigenin
isosilybin
jiaogulan
Jurubeba
kale
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L-glutathione
L-methionine
L-ornithine
lecithin
lingzhi
liquid liver fractions
mangiferin
Maslinic acid
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Milk thistle
Monoterpenes
Mushroom
Myricetin
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Naringenin
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Niacin (vitamin B3)
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nicotinamide riboside
Nigella seed
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oleanolic acid
olive
ornithine L-aspartic acid
ox bile
Oxymatrine
pantethine
parsley
Pentacyclic triterpenoids
phenolic compounds
Phenylpropanoids
phosphatidylcholine
phospholipids
Phthalides
Phyllanthus
picrorhiza kurroa
Picroside
Plukenetia volubilis
Polydatin
polymethoxylated flavones
polyphenols
pu-er tea
Puerarin
pumpkin
punarnava
riboflavin (vitamin B2)
S-allylcysteine
Salvianolic acid
Schisandrins
Schizandrol A
Scoparia dulcis
Sesamin
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Silydianin
silymarin
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sulforaphane glucosinolate
Taraxacum
Taurochenodeoxycholic acid
Taurocholic acid
Taurodeoxycholic acid
Taxifolin
Terminalia
Terpenoids
Theabrownin
Thistle
Thymoquinone
tocotrienols
trace minerals
Trimethylglycine (TMG)
Triphala
Triterpenes
turmeric
vitamin B
Watercress
Wogonin
Xanthohumol
Xanthorrhizol
Yin Chen
Zinc