Evidence supporting the use of: Corilagin
For the body system: Hepatic System
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Corilagin is an ellagitannin compound found in several medicinal plants, such as Phyllanthus urinaria and Terminalia chebula, both of which have a long history of use in traditional medicine, particularly for liver-related ailments. Modern preclinical research provides some scientific basis for its hepatoprotective properties. Several animal and in vitro studies have demonstrated that Corilagin exhibits anti-inflammatory, antioxidant, and anti-fibrotic effects that could be beneficial to the hepatic system. For instance, studies in rodent models of chemically induced liver injury (such as carbon tetrachloride or alcohol-induced damage) have shown that Corilagin can reduce liver enzyme levels, attenuate oxidative stress, and inhibit pathways associated with liver fibrosis and inflammation (e.g., TGF-β/Smad and NF-κB pathways). Additionally, research has indicated that Corilagin may help ameliorate non-alcoholic fatty liver disease (NAFLD) and hepatic fibrosis by modulating inflammatory cytokines and reducing lipid accumulation in the liver.
However, it is important to note that most of the evidence comes from animal studies and cell culture experiments. There are no robust clinical trials in humans that directly confirm these benefits. As such, while there is promising scientific validation at the preclinical level, the overall strength of evidence for Corilagin’s use in supporting the hepatic system in humans remains moderate (rated 3/5).
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AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
animal protein
Antrodia camphorata
apigenin
Arginine carglumate
artichoke
baicalein
barberry
Basidiomycota
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berberine
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betanin
bile acid
bile salt
bitter principals
black garlic
black seed
Boerhavia diffusa
boldo
borotutu
bovine
bovine liver
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broccoli
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bupleurum falcatum
capers
capillary artemisia
carqueja
catalpol
chanca piedra
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chlorogenic acid
cholic acid
Coenzyme A
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cruciferous
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curcumin
Curcuminoid
cynarin
cynaropicrin
d-glucarate
dandelion
dehydrocholic acid
dihydrolipoic acid
dihydromyricetin
dithiolthiones
DL-Methionine
Eclipta
egg
emblicanin
epigallocatechin gallate (EGCG)
eriocitrin
ferulic acid
flavonolignan
fringetree
fungus
gallate
gamma-glutamylcysteine
ganoderma
garlic bulb
gentian root
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glucose
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gooseberry
green tea
Guggulsterones
Gypenoside
herbal blend (proprietary)
hesperetin
isoliquiritigenin
isosilybin
jiaogulan
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L-methionine
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lecithin
lingzhi
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mangiferin
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nicotinamide riboside
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pantethine
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phenolic compounds
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phosphatidylcholine
phospholipids
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pu-er tea
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punarnava
riboflavin (vitamin B2)
S-allylcysteine
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silymarin
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tocotrienols
trace minerals
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turmeric
vitamin B
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