Evidence supporting the use of: Curcuminoid
For the body system: Hepatic System

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Curcuminoids, the active polyphenolic compounds derived from turmeric (Curcuma longa), have been traditionally used in Ayurvedic and Chinese medicine for liver health. Over recent decades, scientific interest has grown regarding their hepatoprotective properties. Preclinical studies (in vitro and animal models) consistently show that curcuminoids exhibit antioxidant, anti-inflammatory, and antifibrotic effects in the liver. These mechanisms are believed to protect hepatocytes from damage induced by toxins, drugs (such as paracetamol), and metabolic stress. Several small-scale clinical trials and systematic reviews indicate potential benefits of curcuminoid supplementation in improving liver enzyme profiles (ALT, AST) and markers of oxidative stress in patients with non-alcoholic fatty liver disease (NAFLD) and other liver disorders. However, the clinical evidence is still limited by small sample sizes, short durations, and variability in curcumin bioavailability and formulation. While the effect size is moderate and not universally consistent, there is a growing body of scientific literature indicating that curcuminoids can support hepatic function, especially as an adjunct to lifestyle interventions. Larger and longer-duration randomized controlled trials are needed to confirm these effects and elucidate optimal dosing and formulation. In summary, curcuminoids are supported by both traditional use and emerging scientific evidence as hepatic system supporters, but the current scientific validation is moderate.

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