Evidence supporting the use of: Cynaropicrin
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cynaropicrin is a sesquiterpene lactone found predominantly in artichoke (Cynara scolymus). Its use to support the hepatic (liver) system is supported by a growing body of scientific evidence, primarily from animal and in vitro studies. Research has demonstrated that cynaropicrin possesses hepatoprotective properties. For instance, studies have shown that cynaropicrin can mitigate liver damage induced by chemicals such as carbon tetrachloride (CCl4) and acetaminophen in animal models, likely due to its antioxidant and anti-inflammatory effects. It appears to modulate pathways associated with oxidative stress and inflammation, both of which are critical in the pathophysiology of liver injury. Additionally, cynaropicrin has been reported to inhibit the activation of hepatic stellate cells, which play a central role in the development of liver fibrosis.

Despite these promising findings in preclinical research, there is currently a lack of robust clinical data in humans to confirm the efficacy and safety of cynaropicrin for hepatic support. Traditional medicine systems have used artichoke extracts (which contain cynaropicrin) for liver health, but the use of isolated cynaropicrin is based on scientific investigation rather than tradition. Therefore, while the scientific rationale exists, more well-designed human studies are needed before cynaropicrin can be firmly recommended for hepatic support.

More about Cynaropicrin
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Other body systems supported by Cynaropicrin

Digestive System
Gastrointestinal Tract
Hepatic System
Liver

Products containing Cynaropicrin

We currently have no products on Vitabase that contain this ingredient.