Evidence supporting the use of: Cysteine compounds (unspecified)
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cysteine compounds, particularly N-acetylcysteine (NAC), are used to support the hepatic (liver) system based on scientific evidence. NAC is a precursor to glutathione, a critical antioxidant in liver cells. It is most notably used as an antidote for acetaminophen (paracetamol) overdose, a scenario in which liver toxicity can be life-threatening. NAC works by replenishing glutathione stores, thereby helping detoxify harmful metabolites in the liver. Several clinical studies and reviews confirm the efficacy of NAC in reducing liver damage in acetaminophen toxicity. Additionally, some research suggests potential benefits in other hepatic disorders characterized by oxidative stress, including non-alcoholic fatty liver disease and alcoholic liver disease, although the evidence here is less robust and largely preliminary.

Other cysteine compounds may also play a role in hepatic support due to their antioxidant properties, but NAC is the most widely studied. Traditional uses of cysteine itself for liver health are not prominent; the support is rooted in modern pharmacology and biochemistry. Overall, while the strongest evidence is for acute toxic injury (such as acetaminophen poisoning), moderate evidence exists for broader liver support, justifying a rating of 3 out of 5 for scientific support.

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