Evidence supporting the use of: Dithiolthiones
For the body system: Hepatic System
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Dithiolthiones are a class of compounds best represented by 1,2-dithiole-3-thione and its derivatives, such as oltipraz. Scientific interest in these molecules centers on their ability to induce phase II detoxification enzymes, particularly those regulated via the Nrf2 pathway. These enzymes, including glutathione S-transferases and quinone reductases, play key roles in hepatic detoxification and protection against oxidative stress and chemical-induced liver damage. Animal and in vitro studies have shown that dithiolthiones can protect the liver from carcinogens and other toxins by upregulating these protective enzymes. Oltipraz, for example, has been studied in clinical trials for its chemopreventive properties in populations at risk for liver cancer, such as those exposed to aflatoxin. While there is moderate scientific evidence from preclinical and a few human studies supporting the hepatoprotective effects of dithiolthiones via enhanced detoxification pathways, the clinical translation to general liver support in the broader population is less well established. Thus, while the use of dithiolthiones is grounded in a plausible scientific mechanism and some supporting evidence, more robust clinical trials are needed to fully justify their widespread use for hepatic support. The current evidence base warrants a moderate rating.
Other ingredients that support Hepatic System
AHCCAlgae
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
animal protein
Antrodia camphorata
apigenin
Arginine carglumate
artichoke
baicalein
barberry
Basidiomycota
Beef liver
berberine
berry
betanin
bile acid
bile salt
bitter principals
black garlic
black seed
Boerhavia diffusa
boldo
borotutu
bovine
bovine liver
Brassica
broccoli
Bupleurum
bupleurum falcatum
capers
capillary artemisia
carqueja
catalpol
chanca piedra
Chinese thoroughwax
chlorogenic acid
cholic acid
Coenzyme A
corilagin
cruciferous
Curcuma
curcumin
Curcuminoid
cynarin
cynaropicrin
d-glucarate
dandelion
dehydrocholic acid
dihydrolipoic acid
dihydromyricetin
dithiolthiones
DL-Methionine
Eclipta
egg
emblicanin
epigallocatechin gallate (EGCG)
eriocitrin
ferulic acid
flavonolignan
fringetree
fungus
gallate
gamma-glutamylcysteine
ganoderma
garlic bulb
gentian root
Gentiana manshurica
Ginsenosides
glucose
Glycochenodeoxycholic acid
Glycocholic acid
Glycyrrhetinic acid
Glycyrrhizin
gooseberry
green tea
Guggulsterones
Gypenoside
herbal blend (proprietary)
hesperetin
isoliquiritigenin
isosilybin
jiaogulan
Jurubeba
kale
Kutkins
L-glutathione
L-methionine
L-ornithine
lecithin
lingzhi
liquid liver fractions
mangiferin
Maslinic acid
Matcha
Milk thistle
Monoterpenes
Mushroom
Myricetin
N-acetyl-cysteine (NAC)
Naringenin
Naringin
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
Nigella seed
Nobiletin
oleanolic acid
olive
ornithine L-aspartic acid
ox bile
Oxymatrine
pantethine
parsley
Pentacyclic triterpenoids
phenolic compounds
Phenylpropanoids
phosphatidylcholine
phospholipids
Phthalides
Phyllanthus
picrorhiza kurroa
Picroside
Plukenetia volubilis
Polydatin
polymethoxylated flavones
polyphenols
pu-er tea
Puerarin
pumpkin
punarnava
riboflavin (vitamin B2)
S-allylcysteine
Salvianolic acid
Schisandrins
Schizandrol A
Scoparia dulcis
Sesamin
Silybin
Silybum
Silychristin
Silydianin
silymarin
Sulforaphane
sulforaphane glucosinolate
Taraxacum
Taurochenodeoxycholic acid
Taurocholic acid
Taurodeoxycholic acid
Taxifolin
Terminalia
Terpenoids
Theabrownin
Thistle
Thymoquinone
tocotrienols
trace minerals
Trimethylglycine (TMG)
Triphala
Triterpenes
turmeric
vitamin B
Watercress
Wogonin
Xanthohumol
Xanthorrhizol
Yin Chen
Zinc