Evidence supporting the use of: Dithiolthiones
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Dithiolthiones are a class of compounds best represented by 1,2-dithiole-3-thione and its derivatives, such as oltipraz. Scientific interest in these molecules centers on their ability to induce phase II detoxification enzymes, particularly those regulated via the Nrf2 pathway. These enzymes, including glutathione S-transferases and quinone reductases, play key roles in hepatic detoxification and protection against oxidative stress and chemical-induced liver damage. Animal and in vitro studies have shown that dithiolthiones can protect the liver from carcinogens and other toxins by upregulating these protective enzymes. Oltipraz, for example, has been studied in clinical trials for its chemopreventive properties in populations at risk for liver cancer, such as those exposed to aflatoxin. While there is moderate scientific evidence from preclinical and a few human studies supporting the hepatoprotective effects of dithiolthiones via enhanced detoxification pathways, the clinical translation to general liver support in the broader population is less well established. Thus, while the use of dithiolthiones is grounded in a plausible scientific mechanism and some supporting evidence, more robust clinical trials are needed to fully justify their widespread use for hepatic support. The current evidence base warrants a moderate rating.

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Other body systems supported by Dithiolthiones

Hepatic System
Liver

Products containing Dithiolthiones

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