Evidence supporting the use of: Fringetree
For the body system: Hepatic System

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Fringetree (Chionanthus virginicus) has a long history of use in traditional herbal medicine, particularly among Native American and 19th-century American herbalists, for supporting the hepatic (liver) system. Historical records and herbal texts describe its use as a “liver tonic” and for treating conditions such as jaundice, gallbladder disorders, and other hepatobiliary complaints. The bark of the plant was commonly prepared as a decoction or tincture for these purposes. However, the primary support for its use is based on tradition rather than modern scientific research.

There is a lack of robust scientific validation for Fringetree’s efficacy in supporting liver function. Few, if any, clinical trials have evaluated its safety or effectiveness in humans for hepatic conditions. Some in vitro and animal studies have identified the presence of compounds such as lignans and secoiridoids, which may have mild anti-inflammatory or choleretic (bile-promoting) effects, but these findings are preliminary and not well-established. Major monographs and herbal references (e.g., the American Herbal Pharmacopoeia, King's American Dispensatory) continue to cite Fringetree primarily based on its traditional applications.

In summary, while Fringetree has a well-documented traditional use for liver and gallbladder support, there is limited scientific evidence to substantiate these claims. Its use in modern herbalism for the hepatic system should be viewed as historically informed rather than scientifically validated.

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AHCC
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alpha-lipoic acid
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AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
animal protein
Antrodia camphorata
apigenin
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artichoke
baicalein
barberry
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berberine
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betanin
bile acid
bile salt
bitter principals
black garlic
black seed
Boerhavia diffusa
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borotutu
bovine
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Bupleurum
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capers
capillary artemisia
carqueja
catalpol
chanca piedra
Chinese thoroughwax
chlorogenic acid
cholic acid
Coenzyme A
corilagin
cruciferous
Curcuma
curcumin
Curcuminoid
cynarin
cynaropicrin
d-glucarate
dandelion
dehydrocholic acid
dihydrolipoic acid
dihydromyricetin
dithiolthiones
DL-Methionine
Eclipta
egg
emblicanin
epigallocatechin gallate (EGCG)
eriocitrin
ferulic acid
flavonolignan
fringetree
fungus
gallate
gamma-glutamylcysteine
ganoderma
garlic bulb
gentian root
Gentiana manshurica
Ginsenosides
glucose
Glycochenodeoxycholic acid
Glycocholic acid
Glycyrrhetinic acid
Glycyrrhizin
gooseberry
green tea
Guggulsterones
Gypenoside
herbal blend (proprietary)
hesperetin
isoliquiritigenin
isosilybin
jiaogulan
Jurubeba
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L-glutathione
L-methionine
L-ornithine
lecithin
lingzhi
liquid liver fractions
mangiferin
Maslinic acid
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Naringenin
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Niacin (vitamin B3)
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nicotinamide riboside
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oleanolic acid
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Oxymatrine
pantethine
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Pentacyclic triterpenoids
phenolic compounds
Phenylpropanoids
phosphatidylcholine
phospholipids
Phthalides
Phyllanthus
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Picroside
Plukenetia volubilis
Polydatin
polymethoxylated flavones
polyphenols
pu-er tea
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pumpkin
punarnava
riboflavin (vitamin B2)
S-allylcysteine
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silymarin
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tocotrienols
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turmeric
vitamin B
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Products containing fringetree

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