Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lingzhi (Ganoderma lucidum), also known as Reishi mushroom, has a long history of use in traditional Asian medicine, particularly for supporting liver (hepatic) health. In recent decades, scientific studies have investigated its effects on the hepatic system. Research has shown that lingzhi contains bioactive compounds such as triterpenoids, polysaccharides, and peptidoglycans, which may have hepatoprotective properties. Animal studies have demonstrated that extracts of Ganoderma lucidum can reduce liver enzyme levels, decrease oxidative stress, and inhibit liver fibrosis in models of chemically-induced liver injury. Some small clinical trials have suggested improvements in liver function tests in patients with hepatitis B, though results are preliminary and sample sizes are limited. Mechanistically, lingzhi appears to exert antioxidant, anti-inflammatory, and immunomodulatory effects relevant to liver health. However, the overall quality of clinical evidence remains moderate, with most studies lacking large sample sizes, blinding, or long-term follow-up. In summary, while traditional use is supported by emerging scientific data suggesting potential benefits for hepatic support, more robust clinical trials are needed to confirm efficacy and safety for liver-related conditions.

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