Evidence supporting the use of: Mangiferin
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Mangiferin, a natural polyphenol primarily found in mangoes (Mangifera indica), has garnered scientific interest for its potential hepatoprotective (liver-protecting) effects. Several in vitro and animal studies have demonstrated that mangiferin exhibits antioxidant, anti-inflammatory, and anti-fibrotic properties, which are relevant to liver health. For example, research published in Phytotherapy Research (2012) and Food and Chemical Toxicology (2013) showed that mangiferin administration could reduce liver enzyme markers of damage (such as ALT and AST), inhibit lipid peroxidation, and improve histological liver changes in rodent models of chemically induced liver injury. These protective effects are attributed to mangiferin's ability to scavenge free radicals, modulate inflammatory cytokines, and enhance endogenous antioxidant enzyme systems such as glutathione peroxidase and superoxide dismutase.

Despite these promising preclinical findings, there is limited evidence from human clinical trials directly investigating mangiferin’s efficacy for supporting liver function or treating liver disorders. Most available data come from animal or cellular studies rather than large-scale human research. As such, while the scientific rationale for using mangiferin to support the hepatic system is supported by mechanistic and early experimental data, definitive clinical validation is still lacking. Therefore, the current strength of evidence is moderate (3/5) and primarily based on preclinical research rather than robust human trials.

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Products containing mangiferin

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