Evidence supporting the use of: Mushrooms
For the body system: Hepatic System

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Mushrooms, particularly medicinal varieties such as Reishi (Ganoderma lucidum), Shiitake (Lentinula edodes), and Turkey Tail (Trametes versicolor), have been investigated for their potential hepatoprotective (liver-supporting) effects. Scientific studies, primarily in animal models and some small human trials, suggest that certain polysaccharides and triterpenoids found in these mushrooms may help protect liver cells from damage, reduce inflammation, and modulate immune responses. For example, research has shown that Reishi extract can decrease markers of liver injury in chemically-induced hepatitis in animals and may have antioxidant properties that help mitigate oxidative stress in the liver. Shiitake mushrooms contain eritadenine and other compounds that may support lipid metabolism and liver health. Turkey Tail has been studied for its immunomodulating effects, which could indirectly support liver health.

However, while preclinical evidence is promising, large-scale, high-quality human clinical trials are limited. Most current evidence comes from laboratory and animal research, with only a few small-scale human studies to date. As a result, while the use of medicinal mushrooms for liver health is justified by preliminary scientific evidence, more rigorous research is needed to fully validate these effects in humans. Therefore, the evidence rating is moderate (3 out of 5), reflecting encouraging but not definitive scientific support.

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