Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Naringin is a flavonoid glycoside predominantly found in grapefruit and other citrus fruits. Scientific studies have indicated that naringin may have hepatoprotective effects, primarily based on in vitro and animal research. The compound appears to exert antioxidant properties, reducing oxidative stress and inflammation in liver tissues. Several rodent studies have shown that naringin administration can protect against chemically-induced liver damage, attenuate fibrosis, and modulate enzymes associated with detoxification in the liver. Proposed mechanisms include the upregulation of endogenous antioxidant enzymes (like superoxide dismutase and catalase), suppression of inflammatory cytokines, and inhibition of lipid peroxidation. However, while these preclinical results are promising, clinical evidence in humans remains limited. There are only a few small-scale human studies, and these are not conclusive regarding efficacy for liver support. Most human data pertains to naringin’s influence on drug metabolism (notably its inhibition of cytochrome P450 enzymes), which can alter the pharmacokinetics of certain medications rather than directly supporting liver health. Therefore, while the preclinical scientific rationale exists and supports further study, the current evidence for naringin’s use in hepatic system support in humans is moderate and not yet definitive.

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Pure Encapsulations Acerola/Flavonoid