Picrorhiza kurroa, commonly referred to as Picrorhiza, has a longstanding history of use in Ayurvedic and other traditional systems of medicine for supporting liver health and treating hepatic disorders. Traditionally, it has been used for conditions such as jaundice, hepatitis, and to stimulate appetite. The herb is prized for its purported “hepatoprotective” properties, and is known as “Kutki” in Ayurveda, where it is described as a potent remedy for liver-related ailments.

Scientific research, while still emerging, provides some support for these traditional uses. Several preclinical studies (in vitro and animal models) have demonstrated that extracts of Picrorhiza kurroa and its active constituents (such as picroside I and II) exhibit hepatoprotective effects, including the ability to mitigate liver damage induced by toxins like carbon tetrachloride and paracetamol. Some mechanisms proposed include antioxidant activity, anti-inflammatory effects, and modulation of liver enzymes. However, well-designed human clinical trials are limited, and the evidence base is not yet robust or conclusive.

In summary, the use of Picrorhiza for hepatic support is primarily justified by a strong tradition of use, with moderate preclinical evidence supporting its hepatoprotective activity. Larger and more rigorous human studies are needed to fully validate its efficacy and safety for liver health.