Evidence supporting the use of: Picroside
For the body system: Hepatic System

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Picroside is a major active compound found in the plant Picrorhiza kurroa, which has been used in traditional Ayurvedic medicine for centuries to support liver health and treat various hepatic disorders. In Ayurveda, Picrorhiza kurroa (known as Kutki) is considered a potent "hepatoprotective" herb and is commonly prescribed for conditions like jaundice, hepatitis, and liver dysfunction.

Some modern preclinical studies (mainly in animal models and in vitro experiments) have identified potential hepatoprotective, antioxidant, and anti-inflammatory effects of picrosides, particularly picroside I and II. These studies suggest that picrosides may help protect liver cells from damage induced by toxins and oxidative stress. However, robust clinical trials in humans are limited, and the evidence base remains incomplete. Systematic reviews often conclude that while there is promising preclinical data, high-quality human studies are lacking.

Therefore, the use of picroside for hepatic support is primarily justified by a long history of traditional use, with some suggestive but not conclusive scientific support. Its role in supporting the hepatic system is recognized in herbal medicine, but mainstream medical guidelines do not endorse its use due to insufficient clinical evidence.

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