Evidence supporting the use of: Polydatin
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polydatin, also known as piceid, is a natural precursor of resveratrol found in Polygonum cuspidatum (Japanese knotweed) and other plants. Its use for supporting the hepatic (liver) system is scientifically investigated, primarily in preclinical studies. Research has demonstrated that polydatin exhibits hepatoprotective effects in various animal models of liver injury, such as those induced by carbon tetrachloride, alcohol, and high-fat diets. The proposed mechanisms include antioxidant activity, reduction of inflammatory cytokines, inhibition of hepatic fibrosis, and modulation of signaling pathways like NF-κB and Nrf2. For example, studies published in peer-reviewed journals report that polydatin administration can attenuate oxidative stress, decrease levels of liver enzymes (ALT, AST), and reduce histopathological changes in liver tissue.

However, while these findings provide promising evidence, most data come from animal or in vitro studies. There are currently limited clinical trials in humans assessing polydatin’s efficacy for liver health. Thus, its use for hepatic support is based on preclinical scientific validation rather than established clinical efficacy or longstanding traditional use specific to the liver. More research, particularly in human populations, is needed to confirm its benefit and safety for hepatic support.

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