Evidence supporting the use of: Polydatin
For the body system: Hepatic System
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Polydatin, also known as piceid, is a natural precursor of resveratrol found in Polygonum cuspidatum (Japanese knotweed) and other plants. Its use for supporting the hepatic (liver) system is scientifically investigated, primarily in preclinical studies. Research has demonstrated that polydatin exhibits hepatoprotective effects in various animal models of liver injury, such as those induced by carbon tetrachloride, alcohol, and high-fat diets. The proposed mechanisms include antioxidant activity, reduction of inflammatory cytokines, inhibition of hepatic fibrosis, and modulation of signaling pathways like NF-κB and Nrf2. For example, studies published in peer-reviewed journals report that polydatin administration can attenuate oxidative stress, decrease levels of liver enzymes (ALT, AST), and reduce histopathological changes in liver tissue.
However, while these findings provide promising evidence, most data come from animal or in vitro studies. There are currently limited clinical trials in humans assessing polydatin’s efficacy for liver health. Thus, its use for hepatic support is based on preclinical scientific validation rather than established clinical efficacy or longstanding traditional use specific to the liver. More research, particularly in human populations, is needed to confirm its benefit and safety for hepatic support.
Other ingredients that support Hepatic System
AHCCAlgae
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
animal protein
Antrodia camphorata
apigenin
Arginine carglumate
artichoke
baicalein
barberry
Basidiomycota
Beef liver
berberine
berry
betanin
bile acid
bile salt
bitter principals
black garlic
black seed
Boerhavia diffusa
boldo
borotutu
bovine
bovine liver
Brassica
broccoli
Bupleurum
bupleurum falcatum
capers
capillary artemisia
carqueja
catalpol
chanca piedra
Chinese thoroughwax
chlorogenic acid
cholic acid
Coenzyme A
corilagin
cruciferous
Curcuma
curcumin
Curcuminoid
cynarin
cynaropicrin
d-glucarate
dandelion
dehydrocholic acid
dihydrolipoic acid
dihydromyricetin
dithiolthiones
DL-Methionine
Eclipta
egg
emblicanin
epigallocatechin gallate (EGCG)
eriocitrin
ferulic acid
flavonolignan
fringetree
fungus
gallate
gamma-glutamylcysteine
ganoderma
garlic bulb
gentian root
Gentiana manshurica
Ginsenosides
glucose
Glycochenodeoxycholic acid
Glycocholic acid
Glycyrrhetinic acid
Glycyrrhizin
gooseberry
green tea
Guggulsterones
Gypenoside
herbal blend (proprietary)
hesperetin
isoliquiritigenin
isosilybin
jiaogulan
Jurubeba
kale
Kutkins
L-glutathione
L-methionine
L-ornithine
lecithin
lingzhi
liquid liver fractions
mangiferin
Maslinic acid
Matcha
Milk thistle
Monoterpenes
Mushroom
Myricetin
N-acetyl-cysteine (NAC)
Naringenin
Naringin
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
Nigella seed
Nobiletin
oleanolic acid
olive
ornithine L-aspartic acid
ox bile
Oxymatrine
pantethine
parsley
Pentacyclic triterpenoids
phenolic compounds
Phenylpropanoids
phosphatidylcholine
phospholipids
Phthalides
Phyllanthus
picrorhiza kurroa
Picroside
Plukenetia volubilis
Polydatin
polymethoxylated flavones
polyphenols
pu-er tea
Puerarin
pumpkin
punarnava
riboflavin (vitamin B2)
S-allylcysteine
Salvianolic acid
Schisandrins
Schizandrol A
Scoparia dulcis
Sesamin
Silybin
Silybum
Silychristin
Silydianin
silymarin
Sulforaphane
sulforaphane glucosinolate
Taraxacum
Taurochenodeoxycholic acid
Taurocholic acid
Taurodeoxycholic acid
Taxifolin
Terminalia
Terpenoids
Theabrownin
Thistle
Thymoquinone
tocotrienols
trace minerals
Trimethylglycine (TMG)
Triphala
Triterpenes
turmeric
vitamin B
Watercress
Wogonin
Xanthohumol
Xanthorrhizol
Yin Chen
Zinc
Other body systems supported by Polydatin
ArteriesBlood
Brain
Capillaries
Circulatory System
Heart
Hepatic System
Immune System
Intestinal System
Kidneys
Liver
Mitochondria
Respiratory System
Skin
Veins