Evidence supporting the use of: Polymethoxylated flavones
For the body system: Hepatic System
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Polymethoxylated flavones (PMFs) are a unique subclass of flavonoids predominantly found in the peels of citrus fruits such as sweet orange and tangerine. Interest in PMFs for hepatic (liver) support stems from their observed antioxidant, anti-inflammatory, and lipid-lowering effects in preclinical research. Several animal studies have demonstrated that PMFs, particularly nobiletin and tangeretin, may protect the liver against toxin-induced damage by reducing oxidative stress and inflammation. For example, studies in rodents have shown that PMFs can attenuate liver injury induced by chemicals such as carbon tetrachloride by modulating signaling pathways involved in inflammation and fibrosis. Furthermore, PMFs have exhibited the ability to improve lipid metabolism and reduce hepatic fat accumulation, suggesting potential benefits in non-alcoholic fatty liver disease (NAFLD) models.
However, while these findings are promising, the majority of evidence comes from in vitro experiments and animal models. Clinical studies in humans examining the effects of PMFs on liver health are very limited. No large-scale, well-controlled human trials have established their efficacy for supporting liver function or treating liver diseases. Thus, current scientific validation is moderate but not definitive, justifying a mid-level evidence score. PMFs are not widely used in traditional medicine specifically for liver support, and their use in this capacity is based on emerging scientific insights rather than historical precedent.
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Other body systems supported by polymethoxylated flavones
ArteriesBlood
Brain
Capillaries
Circulatory System
Heart
Hepatic System
Immune System
Intestinal System
Large Intestines (Colon)
Liver
Lungs
Skin