SAM-e (S-adenosylmethionine) is a compound naturally produced in the body that plays a key role in methylation reactions and liver metabolism. There is significant scientific interest in SAM-e for hepatic (liver) support, particularly in the context of liver diseases such as cholestasis, alcoholic liver disease, and non-alcoholic fatty liver disease. Multiple clinical trials and reviews have investigated its effectiveness.

The scientific rationale for SAM-e use in liver health is based on its role in synthesizing glutathione, a critical antioxidant in liver detoxification. SAM-e levels are often found to be reduced in patients with chronic liver disease. Supplementation has been shown in several studies to improve liver enzyme levels, support bile flow, and reduce markers of oxidative stress in some liver conditions. For example, a 2010 Cochrane review concluded that SAM-e may have a beneficial effect on biochemical markers of liver function, though evidence for long-term clinical outcomes is less robust.

Overall, while SAM-e is not a cure for liver disease, there is scientific validation for its use as a supportive therapy in certain hepatic conditions, especially where traditional therapies are limited or contraindicated. Its safety profile is generally favorable, though it should be used under medical supervision in liver disease patients.