Evidence supporting the use of: Taurodeoxycholic acid
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Taurodeoxycholic acid (TDCA) is a taurine-conjugated bile acid naturally found in human and animal bile. It plays an important role in the hepatic (liver) system, primarily by aiding in the emulsification and absorption of dietary fats and fat-soluble vitamins, which is a core function of bile acids. Scientific studies have demonstrated that TDCA can have hepatoprotective effects, including reducing liver injury and inflammation in various experimental models. For example, animal studies have shown that TDCA can protect hepatocytes from apoptosis (cell death) and oxidative stress, and may help improve bile flow and reduce cholestasis (impaired bile flow). Additionally, TDCA and related bile acids have been investigated for their ability to modulate liver enzymes and promote the excretion of toxic substances via bile. While most of the evidence comes from preclinical (animal or in vitro) studies, the physiological role of TDCA as a native bile acid supports its use in supporting hepatic function. However, direct clinical evidence in humans for supplementation is limited, and most clinical use involves bile acid derivatives such as ursodeoxycholic acid. In summary, there is scientific rationale and preclinical evidence supporting the role of taurodeoxycholic acid in hepatic health, although more human studies are needed to fully validate its therapeutic potential.

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