Theabrownin is a group of complex polyphenolic pigments found primarily in fermented teas, such as Pu-erh tea. Recent scientific studies have investigated the potential hepatoprotective (liver-protecting) effects of theabrownin. Experimental research, mainly in animal models and in vitro studies, suggests that theabrownin may exert beneficial effects on the hepatic system by reducing liver lipid accumulation, modulating oxidative stress, and improving liver enzyme profiles. For example, several studies have shown that theabrownin supplementation can decrease serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), which are biomarkers of liver injury, in rodent models of non-alcoholic fatty liver disease (NAFLD) and chemically-induced liver damage. Mechanistically, theabrownin appears to modulate lipid metabolism pathways, exert antioxidant effects by enhancing endogenous antioxidant enzymes, and reduce inflammatory mediators in the liver.

However, most of the evidence comes from preclinical studies, with only a few small-scale human clinical trials available. While these results are promising and suggest a genuine scientific basis for the use of theabrownin in supporting liver health, larger, well-controlled human studies are needed to confirm its efficacy and safety in clinical settings. Thus, the evidence supporting its use is scientific but currently moderate, justifying a rating of 3 out of 5.