Evidence supporting the use of: Triterpenes
For the body system: Hepatic System

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Triterpenes are a large class of phytochemicals found in a variety of plants, including medicinal herbs such as Ganoderma lucidum (reishi mushroom), Glycyrrhiza glabra (licorice), and Centella asiatica (gotu kola). There is scientific interest in triterpenes for their hepatoprotective (liver-protecting) properties. Several preclinical studies have demonstrated that certain triterpenes, such as glycyrrhizin (from licorice) and ganoderic acids (from reishi), can protect liver cells from damage induced by toxins, alcohol, and other stressors. Mechanisms proposed include antioxidant effects, inhibition of inflammatory mediators, improved liver enzyme profiles, and modulation of hepatic fibrosis pathways.

Clinical evidence is more limited but emerging. Glycyrrhizin, for example, has been used in Japan as an injectable treatment for chronic hepatitis, with some studies reporting improvements in liver function tests and reduced inflammation. However, large-scale, high-quality human trials are still relatively few, and most of the supportive data come from animal models or small pilot studies. Safety considerations (such as the risk of pseudoaldosteronism from licorice-derived triterpenes) also moderate enthusiasm for widespread use.

In summary, there is scientific evidence—predominantly preclinical and some clinical—for the use of triterpenes in supporting liver health, but the strength of evidence is moderate rather than definitive.

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