Evidence supporting the use of: Vitamin B2 (riboflavin 5-phosphate)
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B2, also known as riboflavin or its active form riboflavin 5-phosphate, has a scientifically supported role in hepatic (liver) function, primarily due to its involvement in cellular energy metabolism and its function as a coenzyme in redox reactions. Riboflavin is essential for the activity of flavoproteins, including flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), which are critical in mitochondrial energy production and detoxification processes that occur in the liver. The liver relies heavily on these enzymatic systems for the metabolism of drugs, toxins, and endogenous substances. Deficiency in riboflavin can impair hepatic function and has been associated with increased oxidative stress and reduced detoxification capacity in animal and some human studies. However, while riboflavin is necessary for normal liver function, direct clinical evidence supporting riboflavin supplementation specifically for hepatic disorders in humans is limited. Most support comes from biochemical and mechanistic studies, as well as observations in deficiency states. Therefore, while there is a scientifically plausible rationale for its importance to hepatic health and indirect evidence of benefit, robust clinical trials in liver disease populations are lacking. Overall, the connection between riboflavin and liver health is scientifically valid but not strongly supported by intervention studies targeting hepatic conditions specifically.

More about Vitamin B2 (riboflavin 5-phosphate)
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Other body systems supported by Vitamin B2 (riboflavin 5-phosphate)

Blood
Brain
Digestive System
Eyes
Hepatic System
Immune System
Intestinal System
Liver
Mitochondria
Nerves
Skin

Products containing Vitamin B2 (riboflavin 5-phosphate)

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