Evidence supporting the use of: Vitamin B3 (mixed)
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B3, also known as niacin (nicotinic acid) or niacinamide (nicotinamide), is scientifically recognized for its role in supporting the hepatic (liver) system. Niacin is integral to redox reactions as a component of coenzymes NAD and NADP, which are essential for metabolic processes occurring in the liver, including detoxification and energy production. Clinically, niacin has been used to manage dyslipidemia by lowering LDL cholesterol and triglycerides and raising HDL cholesterol, actions that are processed by the liver. However, high doses of niacin can cause hepatotoxicity, ranging from mild elevation of liver enzymes to severe liver injury, indicating its significant interaction with hepatic function. There is also evidence that vitamin B3 may protect the liver from certain types of damage. Some studies suggest that niacin supplementation can reduce liver inflammation and fibrosis in models of non-alcoholic fatty liver disease (NAFLD), though more research is needed to confirm efficacy in humans. Niacinamide, the amide form, is less likely to cause flushing and hepatotoxicity but still supports liver enzyme activity. In summary, the use of vitamin B3 to support hepatic function is supported by scientific evidence, particularly regarding its metabolic and enzymatic roles in the liver, though caution is warranted with pharmacological doses due to potential toxicity.

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