Evidence supporting the use of: Vitamin B3 (various)
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B3, which includes niacin (nicotinic acid) and niacinamide (nicotinamide), has substantial scientific evidence supporting its role in the hepatic (liver) system. Niacin is well-known for its lipid-lowering effects, which are mediated in part by hepatic mechanisms. It reduces hepatic synthesis of very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) cholesterol and increases high-density lipoprotein (HDL) cholesterol, thereby supporting liver function in lipid metabolism. Clinical studies have demonstrated that niacin therapy can improve serum lipid profiles and may be used adjunctively in treating dyslipidemia, a condition often linked to non-alcoholic fatty liver disease (NAFLD). Additionally, niacin is involved in the synthesis of NAD and NADP, essential coenzymes in cellular metabolism, including detoxification and energy production within hepatocytes. Deficiency of vitamin B3 can result in pellagra, which includes symptoms of hepatic dysfunction among other systemic effects. While niacin is not a primary treatment for liver diseases, its biochemical roles and impact on lipid metabolism provide a strong scientific rationale for supporting hepatic health. However, high doses of niacin can cause hepatotoxicity, and its use should be monitored. The evidence base for its use in hepatic support is robust for its metabolic effects but is less clear regarding direct treatment of liver diseases outside of dyslipidemia.

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