Evidence supporting the use of: Xanthohumol
For the body system: Hepatic System
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Xanthohumol is a prenylated flavonoid found primarily in hops (Humulus lupulus), which are used in beer brewing. There is a growing body of scientific evidence suggesting that Xanthohumol has hepatoprotective (liver-protective) properties. Preclinical studies, including in vitro and animal models, have demonstrated that Xanthohumol exerts antioxidant, anti-inflammatory, and anti-fibrotic effects in the liver. For example, research published in journals such as Archives of Biochemistry and Biophysics and Food and Chemical Toxicology has shown that Xanthohumol can reduce oxidative stress, suppress inflammatory cytokines, and prevent the progression of liver fibrosis in rodent models of liver injury.
Xanthohumol has also been investigated for its role in modulating enzymes involved in detoxification and in reducing fat accumulation in the liver, which are relevant for conditions such as non-alcoholic fatty liver disease (NAFLD). However, most studies to date have been conducted in animals or cell cultures, and there are only limited clinical trials in humans. Thus, while the mechanistic and preclinical data are promising and provide a rationale for supporting hepatic health, high-quality human studies are still needed to confirm efficacy and safety in the context of liver support.
In summary, the use of Xanthohumol to support the hepatic system is primarily justified by scientific evidence from preclinical research, but further clinical validation is necessary.
Other ingredients that support Hepatic System
AHCCAlgae
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
animal protein
Antrodia camphorata
apigenin
Arginine carglumate
artichoke
baicalein
barberry
Basidiomycota
Beef liver
berberine
berry
betanin
bile acid
bile salt
bitter principals
black garlic
black seed
Boerhavia diffusa
boldo
borotutu
bovine
bovine liver
Brassica
broccoli
Bupleurum
bupleurum falcatum
capers
capillary artemisia
carqueja
catalpol
chanca piedra
Chinese thoroughwax
chlorogenic acid
cholic acid
Coenzyme A
corilagin
cruciferous
Curcuma
curcumin
Curcuminoid
cynarin
cynaropicrin
d-glucarate
dandelion
dehydrocholic acid
dihydrolipoic acid
dihydromyricetin
dithiolthiones
DL-Methionine
Eclipta
egg
emblicanin
epigallocatechin gallate (EGCG)
eriocitrin
ferulic acid
flavonolignan
fringetree
fungus
gallate
gamma-glutamylcysteine
ganoderma
garlic bulb
gentian root
Gentiana manshurica
Ginsenosides
glucose
Glycochenodeoxycholic acid
Glycocholic acid
Glycyrrhetinic acid
Glycyrrhizin
gooseberry
green tea
Guggulsterones
Gypenoside
herbal blend (proprietary)
hesperetin
isoliquiritigenin
isosilybin
jiaogulan
Jurubeba
kale
Kutkins
L-glutathione
L-methionine
L-ornithine
lecithin
lingzhi
liquid liver fractions
mangiferin
Maslinic acid
Matcha
Milk thistle
Monoterpenes
Mushroom
Myricetin
N-acetyl-cysteine (NAC)
Naringenin
Naringin
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
Nigella seed
Nobiletin
oleanolic acid
olive
ornithine L-aspartic acid
ox bile
Oxymatrine
pantethine
parsley
Pentacyclic triterpenoids
phenolic compounds
Phenylpropanoids
phosphatidylcholine
phospholipids
Phthalides
Phyllanthus
picrorhiza kurroa
Picroside
Plukenetia volubilis
Polydatin
polymethoxylated flavones
polyphenols
pu-er tea
Puerarin
pumpkin
punarnava
riboflavin (vitamin B2)
S-allylcysteine
Salvianolic acid
Schisandrins
Schizandrol A
Scoparia dulcis
Sesamin
Silybin
Silybum
Silychristin
Silydianin
silymarin
Sulforaphane
sulforaphane glucosinolate
Taraxacum
Taurochenodeoxycholic acid
Taurocholic acid
Taurodeoxycholic acid
Taxifolin
Terminalia
Terpenoids
Theabrownin
Thistle
Thymoquinone
tocotrienols
trace minerals
Trimethylglycine (TMG)
Triphala
Triterpenes
turmeric
vitamin B
Watercress
Wogonin
Xanthohumol
Xanthorrhizol
Yin Chen
Zinc
Other body systems supported by Xanthohumol
ArteriesBrain
Circulatory System
Gastrointestinal Tract
Heart
Hepatic System
Immune System
Intestinal System
Liver