Bergenin is a naturally occurring polyphenol compound isolated from several medicinal plants, including Bergenia ciliata and Bergenia ligulata. Its use in supporting or treating hepatitis has some basis in preclinical scientific studies, though clinical evidence in humans is lacking. Several animal and in vitro studies have demonstrated that bergenin possesses hepatoprotective properties. For example, research published in Phytomedicine and Journal of Ethnopharmacology reported that bergenin can attenuate liver injury induced by toxins such as carbon tetrachloride and paracetamol in rats. The mechanism is believed to involve antioxidant, anti-inflammatory, and membrane-stabilizing activities, as well as modulation of liver enzymes.

Despite these promising findings, the overall quality and quantity of the scientific evidence are limited. Most studies have been conducted in animal models, and there are no high-quality randomized controlled trials in humans specifically evaluating bergenin for hepatitis. Additionally, while bergenin is found in plants traditionally used in Ayurvedic medicine for liver disorders, its use for hepatitis specifically is not well documented in traditional texts. Thus, while bergenin has demonstrated hepatoprotective effects in preclinical research, further studies are needed to establish its efficacy and safety in humans with hepatitis.