Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Black cumin (Nigella sativa) has a longstanding history in traditional medicine for treating a variety of liver disorders, including hepatitis. In recent years, scientific research has begun to investigate its potential hepatoprotective (liver-protecting) effects. Several animal studies suggest that thymoquinone, the main active constituent of black cumin seed oil, possesses antioxidant, anti-inflammatory, and immunomodulatory properties that may protect liver cells from damage induced by toxins or viral infections.

For example, preclinical studies in rats and mice have demonstrated that Nigella sativa extracts can reduce liver enzyme levels (such as ALT and AST), decrease oxidative stress, and improve histopathological features in models of chemically induced hepatitis or liver injury. Some research also suggests thymoquinone may inhibit viral replication in hepatitis-infected cells, though this evidence is limited and mostly in vitro.

However, human clinical trials investigating black cumin in the context of hepatitis are very limited. A few small studies have reported improvements in liver function markers and symptoms in hepatitis C patients, but these trials have methodological weaknesses and need confirmation in larger, well-controlled populations.

In summary, while there is preliminary scientific evidence supporting the potential of black cumin as an adjunct in hepatitis management, it is not strong or conclusive. The rating of "2" reflects promising but early findings, mostly from animal and laboratory research, with insufficient human data to firmly validate its use for hepatitis.

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Designs For Health Annatto-E® Synergy (formerly Annatto Tocotrienols)