Evidence supporting the use of: Black Seed Oil
For the health condition: Hepatitis

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Black seed oil (derived from Nigella sativa) has a long history of traditional use in Middle Eastern and South Asian herbal medicine, including for liver-related ailments such as hepatitis. In traditional medicine systems, black seed is believed to have hepatoprotective, anti-inflammatory, and immune-modulating properties. However, scientific research specifically validating its efficacy for hepatitis (especially chronic viral hepatitis B or C) in humans is limited and mainly preclinical. Some animal studies demonstrate that thymoquinone, the main active compound in black seed oil, can reduce liver inflammation, oxidative stress, and injury markers, and may have antiviral activity in vitro. A small number of early-stage clinical studies suggest black seed oil might improve some liver function parameters, but these are not hepatitis-specific and are often underpowered.

No large, well-designed clinical trials have confirmed black seed oil’s effectiveness or safety for treating hepatitis in humans. Therefore, while its use for hepatitis is justified by traditional practices and there is some low-level scientific plausibility based on mechanistic and animal studies, current evidence is not strong enough to recommend it as a primary or adjunct therapy for hepatitis. Individuals considering its use should consult healthcare professionals, especially since hepatitis is a serious medical condition requiring evidence-based treatment.

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