Celosia species, particularly Celosia argentea (also known as cockscomb), have a long history of use in traditional medicine systems, especially in parts of Asia and Africa. In Traditional Chinese Medicine (TCM), Celosia seeds (known as "Qing Xiang Zi") are used for their purported cooling and detoxifying properties, believed to help in conditions associated with "heat" in the liver, which sometimes includes hepatitis-like symptoms. Similarly, in African ethnomedicine, decoctions of Celosia leaves or seeds are sometimes used to address liver disorders and jaundice.

As for scientific evidence, there are a few preliminary pharmacological studies suggesting that extracts from Celosia may exhibit hepatoprotective effects in animal models, potentially due to antioxidant or anti-inflammatory activity. However, these studies are limited in number, generally preclinical, and do not directly validate efficacy for hepatitis in humans. No robust clinical trials exist to support the use of Celosia for treating or managing hepatitis in modern medicine. Thus, its use for hepatitis is justified primarily by traditional practices rather than by scientific validation.

In summary, while Celosia is traditionally used for liver-related ailments, including hepatitis, scientific evidence supporting this use is minimal and preliminary. Its application should be viewed within the context of traditional medicine rather than as an evidence-based treatment.