Evidence supporting the use of: Epigallocatechin
For the health condition: Hepatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epigallocatechin, particularly in the form of epigallocatechin-3-gallate (EGCG) found in green tea, has been studied for its potential hepatoprotective effects, including use in hepatitis. Laboratory and some animal studies have shown that EGCG can exert antiviral, anti-inflammatory, and antioxidant properties, which are beneficial in the context of liver diseases such as viral hepatitis (HBV, HCV) and non-viral hepatitis models. For instance, EGCG has demonstrated the ability to inhibit hepatitis B virus (HBV) DNA synthesis and suppress hepatitis C virus (HCV) replication in vitro. Additionally, EGCG’s antioxidant activity may protect liver cells from oxidative stress-induced damage commonly seen in hepatitis. However, while these preclinical findings are promising, clinical evidence in humans is limited. A few small-scale clinical studies have explored green tea extracts in liver disease, but results are inconclusive and often confounded by methodological limitations. No large randomized controlled trials have definitively proven the efficacy or safety of epigallocatechin for treating hepatitis in humans. Moreover, high doses of green tea extracts have, in rare cases, been associated with hepatotoxicity. In summary, the use of epigallocatechin for hepatitis is supported by preclinical scientific research, but human evidence remains preliminary and insufficient for routine clinical recommendation.

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