Evidence supporting the use of: Immunoglobulins
For the health condition: Hepatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Immunoglobulins, specifically hepatitis B immune globulin (HBIG), have well-established scientific support for their use in the prophylaxis and treatment of hepatitis B infection. HBIG contains high titers of anti-HBs antibodies and is used in post-exposure prophylaxis for individuals exposed to hepatitis B virus (HBV), such as newborns of HBsAg-positive mothers, healthcare workers after needle-stick injuries, and individuals with sexual or household exposure to an infected person. HBIG is also used in combination with hepatitis B vaccination to prevent infection following exposure.

Clinical studies have demonstrated that administration of HBIG, especially when given within 24 hours of exposure, significantly reduces the risk of developing HBV infection. For chronic hepatitis B patients undergoing liver transplantation, HBIG is used alongside antiviral agents to prevent reinfection of the graft. The use of immune globulin for hepatitis A (IG) is similarly supported for pre- and post-exposure prophylaxis, especially in non-immune individuals, travelers to endemic areas, or those at high risk of severe disease.

There is, however, no role for immunoglobulins in the treatment of hepatitis C, as no specific immune globulin product is effective against HCV. Overall, the use of immunoglobulins for hepatitis A and B is scientifically validated and forms part of established medical guidelines for prevention and post-exposure management.

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