Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glutathione is a tripeptide composed of glutamine, cysteine, and glycine, and is considered a major endogenous antioxidant in the human body. Its use in supporting or treating hepatitis, particularly in chronic hepatitis B and C, is primarily justified by its biochemical role in protecting hepatocytes from oxidative stress and supporting detoxification processes.

Several scientific studies have examined glutathione levels in patients with hepatitis, finding that these levels are often depleted during active disease, which may contribute to liver damage. Some small clinical trials and animal studies have suggested that supplementation with glutathione or its precursors (such as N-acetylcysteine) may help restore hepatic glutathione levels, reduce markers of oxidative stress, and potentially improve liver function parameters.

However, evidence is limited and of variable quality. Most studies are small, open-label, or lack placebo controls. Systematic reviews highlight a need for larger, well-designed randomized controlled trials to confirm clinical benefits, as most current evidence focuses on surrogate biochemical markers rather than hard clinical endpoints such as disease progression, fibrosis, or survival.

In summary, the use of L-glutathione for hepatitis is based on plausible biochemical mechanisms and preliminary clinical data, but robust scientific validation is lacking. Thus, while it is a scientifically grounded intervention with some supportive evidence, its efficacy and role in hepatitis management remain to be firmly established.

More about L-glutathione
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