Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Oleanolic acid is a naturally occurring triterpenoid compound found in various plants, including olives and medicinal herbs. Its use in supporting or treating hepatitis, especially hepatitis B and C, has been investigated both in traditional medicine and in modern scientific research. In traditional Chinese medicine, herbs containing oleanolic acid have been used to manage liver disorders for centuries. However, the scientific basis for its use has grown in recent decades. Preclinical studies have demonstrated that oleanolic acid possesses hepatoprotective, anti-inflammatory, and antiviral properties. Animal models and in vitro studies indicate that oleanolic acid can reduce liver inflammation, inhibit viral replication, and protect hepatocytes from damage induced by toxins and viral infections. Several small-scale clinical studies in China have also reported improvements in liver function markers (such as ALT and AST) in hepatitis patients treated with oleanolic acid or its derivatives. Nevertheless, the overall clinical evidence is limited by small sample sizes, study design flaws, and a lack of large, randomized controlled trials. As a result, while there is promising preliminary scientific evidence supporting the use of oleanolic acid for hepatitis, its efficacy and safety are not yet fully established, and it is not considered a standard treatment in evidence-based clinical guidelines.

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